Purkinje Neurons and Glia of Rat Cerebellum
Double fluorescent labeled thin sectionTechnique:
Purkinje neurons are some of the largest and most complex cells in the mammalian brain, possessing diameters almost as large as a human hair. Each of the cells exhibits an abundance of very active dendrites and is capable of receiving input from over 200,000 other cells. Yet, Purkinje neurons are the lone source of output from the cerebellum’s cortex. Their primary function is believed to be inhibitory, selectively suppressing and limiting excitatory impulses from other cells and crafting them into a coherent message that the rest of the brain can understand.